RESEARCH THEME

"Addressing the global burden of cardiometabolic disease requires approaches that connect laboratory discoveries with patient care. Through collaborative efforts between Thailand and Canada, the Thai-Canada Research Center (TCRC) brings together expertise in molecular biology, clinical medicine, and bioinformatics to uncover complex biological mechanisms and accelerate the translation of scientific discoveries into innovative and improved patient care."

By enriching the understanding of interactions among gut microbiome dysbiosis, adiponectin signaling, and metabolic dysfunction, they are able to identify potential biomarkers and therapeutic targets for earlier diagnosis and treatment. These suggest that EV lipid profiles, microbial species, and metabolites may serve as biomarkers for cardiometabolic disease, while targeting adiponectin signaling or the gut microbiome may provide novel therapeutic strategies.

However, many studies remain exploratory and rely on preclinical models or small cohorts. Hence, standardized methodologies, larger, diverse cohorts, and further clinical validation are required before initiating translation into clinical practice.​