TCRC PUBLICATIONS

The Thai-Canada Research Center has published several papers in collaboration with professors from Srinakharinwirot University and York University to broaden understanding of cardiometabolic disease. Throughout innovative research, the Center has contributed to several reviewed publications that explore the biological pathways and interactions underlying these conditions and identify potential therapeutic strategies for earlier diagnosis and improved treatment.

One study, utilizing mouse test subjects, illustrates that adiponectin deficiency remodeled the lipid composition of plasma extracellular vesicles (EVs) - small particles released by cells that play a vital role in cell-to-cell communication. For the TCRC, this identifies EV lipid composition as a promising biomarker for detecting early cardiometabolic disease and supports adiponectin-based therapies to restore healthy EV function.​

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Another study combined metabolomic and gut microbiome analyses to identify a distinct biological signature associated with metabolic syndrome. Patients with metabolic syndrome showed reduced gut microbial diversity, with 20 microbial species significantly associated with the condition. These findings highlight the potential for developing microbiome-based interventions, including dietary strategies and probiotics, to improve cardiometabolic health.